| Identifier | HPI104051 |
| Interaction | p73 <==> p53 |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000114,activation; IT:0000271,express; IT:0000280,relate; IT:0000176,suppress; |
| Biological Process | BP:0032502,development; BP:0016446,mutation; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0005694,chromosome; |
| Detection Method | --- |
| Reference | 10362118_0, Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver.
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| Reference | 10362118_1, p73, the first homologue of the tumour suppressor protein p53, was recently discovered on chromosome 1p36 and has been shown to induce apoptosis in a p53-like manner.
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| Reference | 10362118_12, We failed to observe a correlation between p73 expression or p53 and apoptosis within a given tumour.
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| Reference | 10362118_15, Our results with a high prevalence of p73 within tumours harbouring mutated p53 gene suggest that p73 could compensate for p53 function.
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| Reference | 10706549_2, Recently, a novel gene, p73, has been identified at 1p36.33. p73 is structurally and functionally related to p53 located at 17p13.1, which is a target for inactivation in HCCs. p73 produces at least two splicing variants, p73alpha and beta, and a polymorphism in exon 2 results in two alleles, GC or AT.
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| Reference | 10928060_1, p73, a structural homologue of the tumor suppressor gene, p53, has recently been identified and mapped to chromosome 1p36, where genomic loss of heterozygosity (LOH) often occurs in human hepatocellular carcinoma (HCC).
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| Reference | 10928060_2, To determine whether p73 is involved in the development of HCC and whether there is an inverse correlation between the mutations of p73 and p53, we examined 22 paired tumors/noncancerous liver tissues for allelic expression, LOH and mutation of p73 and for mutation of p53. p73 was biallelically expressed in noncancerous liver tissues and in 7 out of the 8 informative tumors.
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| Reference | 11991598_1, p73 is the first identified homolog of p53, but its function has not been established.
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| Reference | 12546528_1, p73 is one of the family proteins that share structural and functional homologies with the tumor suppressor p53.
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| Reference | 14719122_1, A novel gene, p73, encoding a protein with significant homology to p53 and showing functional similarities to p53, was identified at chromosome 1p36, at which tumor suppressor gene of hepatocellular carcinoma (HCC) is supposed to be.
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| Reference | 14719122_13, These findings suggested that p73 might play some role in tumor progression of HCC even though p73 should not be considered a candidate gene on chromosome 1p of HCC and does not function as a tumor suppressor gene like p53.
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