| Identifier | HPI112521 |
| Interaction | ubiquitin ligase <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000128,phosphorylation; IT:0000092,degradation; IT:0000123,ubiquitination; |
| Biological Process | --- |
| Biological Function | BF:0016874,ligase activity; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 15625077_6, Ser166 phosphorylation of Mdm2 has been associated to active Mdm2 and has been shown to increase its ubiquitin ligase activity and lead to increased p53 degradation.
|
| Reference | 17107963_11, Ser-166 phosphorylation of Mdm2 has been shown to increase its ubiquitin ligase activity and increase p53 degradation, and our data indicated an attenuated p53 response to DNA damage in hepatocytes exhibiting high levels of pMdm2 Ser-166.
|
| Reference | 21060154_4, We found that Enigma elicited p53 degradation by inhibiting MDM2 self-ubiquitination and increasing its ubiquitin ligase activity toward p53 in cells.
|
| |
|