Detail information of PPI "MPI07468"

IdentifierMPI07468
InteractionCdk2 ( - / - ) mouse embryonic fibroblasts  <==>  p53
Role & State        ---
Interaction TypeIT:0000114,activation; IT:0000357,response;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference17942597_4, Cdk2(-/-) mouse embryonic fibroblasts in vitro as well as regenerating liver cells after partial hepatectomy (PH) in Cdk2(-/-) mice, arrest promptly at the G1/S checkpoint in response to gamma-irradiation due to activation of p53 and p21 inhibiting Cdk1.