Detail information of PPI "MPI10694"

IdentifierMPI10694
InteractionFTY720  <==>  p53
Role & State        ---
Interaction TypeIT:0000139,dephosphorylation; IT:0000128,phosphorylation;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference15297371_10, In conclusion, FTY720 is a novel anticancer agent that induces apoptosis of hepatoma cell lines both in vitro and in vivo through PI3-K-mediated Akt dephosphorylation in a p53-independent manner.