Detail information of PPI "MPI17560"

IdentifierMPI17560
InteractionIRF-1  <==>  p53
Role & State        ---
Interaction TypeIT:0000114,activation; IT:0000295,affect; IT:0000078,regulation;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference9472983_6, IRF-1 deficiency did not affect the p53-dependent G1/S arrest after UV irradiation.
Reference9472983_8, However, IRF-1 deficiency produced dysregulation of p53, manifested as increased transactivation of a p53-reporter plasmid in undamaged hepatocytes, and accelerated p53 stabilization after DNA damage.