| Identifier | MPI47402 |
| Interaction | p21 <==> p53 |
| Role & State | RS:0000074,inhibitor; RS:0000077,regulator; RS:0000080,suppressor; |
| Interaction Type | IT:0000089,addition; IT:0000078,regulation; |
| Biological Process | BP:0016049,cell growth; BP:0007049,cell cycle; BP:0006915,apoptosis; BP:0040007,growth; BP:0008283,cell proliferation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 9049198_2, In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbeta), differentiation, and apoptosis.
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| Reference | 11350897_1, IFN regulatory factor-1 (IRF-1) regulates the IFN system, inhibits cell growth, and has tumor-suppressor activities. p21 is a universal cyclin-dependent kinase inhibitor, the induction of which depends on both p53 and IRF-1 in mouse embryonic fibroblasts.
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| Reference | 14647424_1, Using Cre-Lox technology to inducibly delete Rb from wild-type, p21- and/or p53-deficient primary hepatocytes, we investigated the role of p53, p21 and pRb in the regulation of liver cell proliferation, polyploidization and death.
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