| Identifier | MPI47590 |
| Interaction | p53 <==> AFP |
| Role & State | RS:0000077,regulator; RS:0000078,repressor; |
| Interaction Type | IT:0000174,repress; IT:0000364,acetylation; IT:0000132,methylation; IT:0000068,transcription; |
| Biological Process | BP:0032502,development; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000785,chromatin; |
| Detection Method | DM:0000019,immunoprecipitation; |
| Reference | 15743813_5, Hepatic expression of AFP correlates with FoxA interaction at the repressor region and the binding of RNA polymerase II and TATA-binding protein to the core promoter. p53 acts as a developmental repressor of AFP in the liver by binding to chromatin, excluding FoxA interaction and targeting mSin3A/HDAC1 to the distal repressor region. p53-null mice exhibit developmentally delayed AFP repression, concomitant with acetylation of H3K9, methylation of H3K4, and loss of DiMetH3K9, mSin3A/HDAC1, and HP1 interactions.
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| Reference | 18212064_1, In hepatic cells, Smad and SnoN proteins converge with p53 to repress transcription of AFP, an oncodevelopmental tumor marker aberrantly reactivated in hepatoma cells.
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| Reference | 18212064_4, Sequential chromatin immunoprecipitation analyses and molecular modeling indicate that p53 and Smad proteins simultaneously occupy overlapping p53 and Smad regulatory elements to establish repression of AFP transcription.
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