| Identifier | MPI47597 |
| Interaction | p53 <==> Bax |
| Role & State | --- |
| Interaction Type | IT:0000093,depletion; |
| Biological Process | BP:0006626,mitochondrial translocation; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000031,mitochondrial membrane; SCL:0000003,membrane; SCL:0000008,nucleus; SCL:0000014,mitochondria; |
| Detection Method | DM:0000051,fluorescence; |
| Reference | 11343247_10, Thiol depletion could cause oxidative stress that requires several hours to increase p53; the latter induces Bax, which translocates to mitochondria after Fas stimulation.
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| Reference | 14729587_7, Fluorescence microscopic analysis revealed a translocation of p53 to the nucleus and of Bax to the mitochondria.
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| Reference | 18504456_0, p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity.
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