| Identifier | MPI47623 |
| Interaction | p53 <==> H3K4 me2 |
| Role & State | --- |
| Interaction Type | IT:0000068,transcription; IT:0000114,activation; IT:0000138,demethylation; IT:0000132,methylation; |
| Biological Process | BP:0032502,development; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000785,chromatin; |
| Detection Method | DM:0000019,immunoprecipitation; |
| Reference | 18573881_3, Chromatin immunoprecipitation (ChIP) and sequential ChIP of developmentally staged liver showed that p53 and LSD1 cooccupy a p53 response element, concomitant with dimethylated histone H3 lysine 4 (H3K4me2) demethylation and postnatal repression of AFP transcription.
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| Reference | 18573881_5, We performed partial hepatectomy of wild-type mouse liver and induced a regenerative response, which led to a loss of p53, increased H3K4me2, and decreased LSD1 interaction at AFP chromatin, in parallel with reactivation of AFP expression.
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