| Identifier | MPI47641 |
| Interaction | p53 <==> MDM2 |
| Role & State | --- |
| Interaction Type | IT:0000092,degradation; IT:0000073,attachment; IT:0000076,inhibition; IT:0000290,form; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17363365_7, Finally, ubiquitinated p53 accumulated in a pAb-240 reactive form when p53 degradation was blocked by proteasome inhibition, and a p53-ubiquitin fusion protein displayed a mutant-only conformation in MDM2-null cells.
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| Reference | 17363365_9, The covalent attachment of ubiquitin may lock p53 in a mutant conformation in the absence of MDM2-binding and prior to its degradation by the proteasome.
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