Detail information of PPI "MPI47697"

IdentifierMPI47697
Interactionp53  <==>  p53 response element
Role & State        ---
Interaction TypeIT:0000138,demethylation; IT:0000132,methylation; IT:0000068,transcription;
Biological ProcessBP:0032502,development;
Biological Function        ---
Subcelluar LocationSCL:0000785,chromatin;
Detection MethodDM:0000019,immunoprecipitation;
Reference18573881_3, Chromatin immunoprecipitation (ChIP) and sequential ChIP of developmentally staged liver showed that p53 and LSD1 cooccupy a p53 response element, concomitant with dimethylated histone H3 lysine 4 (H3K4me2) demethylation and postnatal repression of AFP transcription.