| Identifier | HPI031764 |
| Interaction | HBx protein <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000068,transcription; IT:0000168,inhibit; IT:0000124,transactivation; IT:0000114,activation; IT:0000078,regulation; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | BF:0002039,p53 binding; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10074921_3, Our previous work has shown that HBx protein inhibits p53 sequence-specific transcriptional activation, p53-mediated apoptosis and p53 binding to the TFIIH transcription-nucleotide excision repair (NER) factors, including XPB and XPD.
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| Reference | 16940298_7, Down-regulation of the HBx protein level by p53 also reduced HBx-mediated cyclin D1 up-regulation.
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| Reference | 9405677_5, The transcriptional transactivation domain of HBx also maps to its C terminus; however, a comparison of the ability of full-length and truncated HBx protein to abrogate p53-induced apoptosis versus transactivate simian virus 40- or human nitric oxide synthase-2 promoter-driven reporter constructs indicates that these two functional properties are distinct and thus may contribute to hepatocarcinogenesis differently.
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