Detail information of PPI "HPI032023"

IdentifierHPI032023
InteractionHCV NS5A  <==>  p53
Role & State        ---
Interaction TypeIT:0000076,inhibition; IT:0000068,transcription; IT:0000242,direct; IT:0000026,interact; IT:0000114,activation;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar LocationSCL:0000006,cytoplasm;
Detection Method        ---
Reference12101418_0, HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
Reference12101418_11, These results suggest that HCV NS5A interacts with and partially sequestrates p53 and hTAF(II)32 in the cytoplasm and suppresses p53-mediated transcriptional transactivation and apoptosis during HCV infection, which may contribute to the hepatocarcinogenesis of HCV infection.
Reference12101418_5, HCV NS5A binds directly to p53 and colocalizes p53 in the perinuclear region.
Reference16042885_0, [Molecular mechanism of HCV NS5A on p53's inhibition of AFP expression in hepatocellular carcinoma cells].