Identifier | HPI032023 |
Interaction | HCV NS5A <==> p53 |
Role & State | --- |
Interaction Type | IT:0000076,inhibition; IT:0000068,transcription; IT:0000242,direct; IT:0000026,interact; IT:0000114,activation; |
Biological Process | BP:0006915,apoptosis; |
Biological Function | --- |
Subcelluar Location | SCL:0000006,cytoplasm; |
Detection Method | --- |
Reference | 12101418_0, HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
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Reference | 12101418_11, These results suggest that HCV NS5A interacts with and partially sequestrates p53 and hTAF(II)32 in the cytoplasm and suppresses p53-mediated transcriptional transactivation and apoptosis during HCV infection, which may contribute to the hepatocarcinogenesis of HCV infection.
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Reference | 12101418_5, HCV NS5A binds directly to p53 and colocalizes p53 in the perinuclear region.
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Reference | 16042885_0, [Molecular mechanism of HCV NS5A on p53's inhibition of AFP expression in hepatocellular carcinoma cells].
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