Detail information of PPI "HPI033373"

IdentifierHPI033373
InteractionHIF-1  <==>  p53
Role & State        ---
Interaction TypeIT:0000071,induction; IT:0000068,transcription;
Biological ProcessBP:0040007,growth;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference15592500_4, Further, we provide genetic evidence that induction of Ero1-L alpha by hypoxia and hypoglycemia is mediated by the transcription factor hypoxia-inducible factor 1 (HIF-1) but is independent of p53.
Reference19696166_7, On the contrary, nutlin-3 blunted the hypoxic induction of vascular endothelial growth factor by inactivating HIF-1 even in p53-null cells.