| Identifier | HPI039362 |
| Interaction | IGF-II <==> p53 |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000280,relate; IT:0000099,formation; |
| Biological Process | BP:0040007,growth; BP:0006260,replication; BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 8565758_2, In this study, we analyzed the relationship of HCV replication with mRNA expression of growth factors and mutation of tumor suppressor gene, ie, transforming growth factor-beta 1 (TGF-beta 1), which promotes cirrhotic changes; TGF-alpha, insulin-like growth factor-II (IGF-II), which are both related to hepatocyte transformation; and tumor suppressor gene p53, which is associated with HCC progression. |