| Identifier | HPI042095 |
| Interaction | IRF-1 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000114,activation; IT:0000078,regulation; IT:0000200,repair; IT:0000130,overexpression; IT:0000219,produce; |
| Biological Process | BP:0007050,cell cycle arrest; BP:0006281,DNA repair; BP:0007049,cell cycle; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17550137_8, Overexpression of IRF-1 augmented the combined interferon-gamma/adriamycin-induced p53 accumulation.
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| Reference | 9472983_4, Here, we report the consequences of IRF-1 deficiency for apoptosis, cell cycle arrest, and DNA repair in primary hepatocytes after DNA damage and extend previous work on the role of p53 in hepatocytes.
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| Reference | 9472983_8, However, IRF-1 deficiency produced dysregulation of p53, manifested as increased transactivation of a p53-reporter plasmid in undamaged hepatocytes, and accelerated p53 stabilization after DNA damage.
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