| Identifier | HPI049639 |
| Interaction | MDM2 <==> p53 |
| Role & State | RS:0000080,suppressor; RS:0000002,activity; |
| Interaction Type | IT:0000114,activation; IT:0000176,suppress; IT:0000123,ubiquitination; IT:0000092,degradation; IT:0000076,inhibition; IT:0000290,form; IT:0000168,inhibit; IT:0000068,transcription; IT:0000026,interact; IT:0000130,overexpression; IT:0000264,antagonize; IT:0000099,formation; IT:0000266,disruption; IT:0000227,bind; IT:0000059,binding; |
| Biological Process | BP:0040007,growth; BP:0008219,cell death; BP:0042254,ribosome biogenesis; BP:0006915,apoptotic cell death; |
| Biological Function | BF:0016563,transcriptional activity; |
| Subcelluar Location | SCL:0000016,ribosome; SCL:0005694,chromosome; |
| Detection Method | --- |
| Reference | 11982701_1, Chromosome 9p21, a locus comprising the tumor suppressor genes (TSG) p16(INK4a) and p14(ARF), is a common region of loss of heterozygosity (LOH) in hepatocellular carcinoma (HCC). p14(ARF) shares exon 2 with p16 in a different reading frame. p14 binds to MDM2 resulting in a stabilization of functional p53.
|
| Reference | 17363365_0, MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation.
|
| Reference | 17545619_2, MDM2 interaction with p53 results in ubiquitination and 26S proteasomal degradation of p53.
|
| Reference | 17545619_3, Chronic DNA damage leads to inactivation of MDM2, stabilization of p53, and apoptotic cell death.
|
| Reference | 18161051_1, Gankyrin (also known as PSMD10) is a liver oncoprotein that interacts with multiple proteins including MDM2 and accelerates degradation of the tumor suppressors p53 and Rb.
|
| Reference | 19098711_2, Here, we report that RYBP (RING1- and YY1-binding protein), a member of the polycomb group (PcG), interacts with MDM2 and decreases MDM2-mediated p53 ubiquitination, leading to stabilization of p53 and an increase in p53 activity.
|
| Reference | 19287375_1, Impaired ribosome biogenesis is attributed to nucleolar disruption and diffusion of a subset of 60S ribosomal proteins, particularly ribosomal protein (rp)L11, into the nucleoplasm, where they inhibit MDM2, leading to p53 induction and cell-cycle arrest.
|
| Reference | 19513507_5, Further, tumor suppressor p53 was overexpressed in two arsenic-resistant cell lines, but the levels of p53 mediators MDM2 and gankyrin, which regulate the ubiquitination of p53, increased simultaneously.
|
| Reference | 20849854_2, In the current study, we found that an increase in SCYL1-BP1 protein levels caused a parallel change in the amount of p53 protein due to the inhibition by SCYL-BP1 of MDM2-mediated p53 ubiquitination.
|
| Reference | 21060154_1, The human E3 ubiquitin ligase murine double minute 2 (MDM2) targets the tumor suppressor p53 for ubiquitination and degradation but also promotes its own ubiquitination and subsequent degradation.
|
| Reference | 21060154_3, Here we have shown that the LIM domain protein Enigma directly interacts with MDM2 to form a ternary complex with p53 in vitro and in human hepatoma and colon carcinoma cell lines and mouse embryonic fibroblasts.
|
| Reference | 21261729_0, MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro.
|
| Reference | 21563203_8, Whereas KLF6 overexpression in HCC cell lines and primary hepatocytes led to reduced MDM2 levels and increased p53 protein and transcriptional activity, reduction in KLF6 by small interfering RNA led to increased MDM2 and reduced p53.
|
| Reference | 9891508_5, MDM2 is a normal cell protein which antagonizes p53, amplification is seen in some human sarcomas.
|
| |
|