| Identifier | HPI054935 |
| Interaction | Notch1 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000092,degradation; IT:0000271,express; IT:0000078,regulation; IT:0000076,inhibition; IT:0000176,suppress; IT:0000157,depend; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 19376776_6, Inhibition of the Akt/Hdm2 pathway by Notch1 signaling was responsible for the suppression of p53 proteasomal degradation, thus contributing to the Notch1 signaling-mediated up-regulation of p53 expression.
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| Reference | 19376776_8, The data suggest that enhancement of TRAIL-induced apoptosis by Notch1 signaling is dependent upon p53 up-regulation.
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| Reference | 19376776_9, Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner.
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| Reference | 21480340_7, Notch1 expression was correlated with p53 expression in cells expressing p53WT, but was not elevated in p53Mut-expressing cells.
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