Detail information of PPI "HPI057596"

IdentifierHPI057596
InteractionPAX5  <==>  p53
Role & StateRS:0000080,suppressor;
Interaction TypeIT:0000078,regulation; IT:0000287,activate; IT:0000242,direct; IT:0000077,regulate;
Biological ProcessBP:0040007,growth; BP:0023033,signaling pathway; BP:0070265,necrosis;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference21319196_12, The pathway luciferase reporter assay indicated that PAX5 activated p53 and p21 signaling.
Reference21319196_14, The antitumorigenic function of PAX5 was at least up-regulated by p53 and its downstream targets including tumor necrosis factor, Fas ligand, leucine-rich repeats, and death domain-containing, poly(rC) binding protein 4, p21, and growth arrest and DNA-damage-inducible alpha.
Reference21319196_16, PAX5 appears to be a functional tumor suppressor involved in liver carcinogenesis through direct regulation of the p53 signaling pathway.