Identifier | HPI057596 |
Interaction | PAX5 <==> p53 |
Role & State | RS:0000080,suppressor; |
Interaction Type | IT:0000078,regulation; IT:0000287,activate; IT:0000242,direct; IT:0000077,regulate; |
Biological Process | BP:0040007,growth; BP:0023033,signaling pathway; BP:0070265,necrosis; |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 21319196_12, The pathway luciferase reporter assay indicated that PAX5 activated p53 and p21 signaling.
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Reference | 21319196_14, The antitumorigenic function of PAX5 was at least up-regulated by p53 and its downstream targets including tumor necrosis factor, Fas ligand, leucine-rich repeats, and death domain-containing, poly(rC) binding protein 4, p21, and growth arrest and DNA-damage-inducible alpha.
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Reference | 21319196_16, PAX5 appears to be a functional tumor suppressor involved in liver carcinogenesis through direct regulation of the p53 signaling pathway.
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