| Identifier | HPI058588 |
| Interaction | PFTalpha <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000168,inhibit; IT:0000099,formation; IT:0000114,activation; IT:0000025,associate; |
| Biological Process | BP:0006915,apoptosis; BP:0008152,metabolism; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 16258175_1, Pifithrin alpha (PFTalpha) is a chemical compound that inhibits p53-mediated gene activation and apoptosis.
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| Reference | 16258175_7, Blockage of CYP1 activity by PFTalpha was associated with a decreased metabolism of BP, a reduced formation of BP-derived adducts and a diminished BP-induced apoptosis in human cultured cells targets for PAHs like primary human macrophages and p53-negative KG1a leukaemia cells.
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