| Identifier | HPI061471 |
| Interaction | PTX-2 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000242,direct; |
| Biological Process | BP:0032502,development; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 18202802_10, Although further studies are needed to prove that an increased expression of Egr-1 by PTX-2 directly leads to NAG-1 induction and then apoptosis induction in p53-deficient Hep3B cells, the results of this study suggest that PTX-2 may be a good candidate for the development of a potential anti-tumorigenic agent in p53-deficient tumors.
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| Reference | 18202802_4, Pectenotoxin-2 (PTX-2), isolated from marine sponges has been reported to display significant cytotoxicity to p53-deficient cancer cell lines.
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