| Identifier | HPI062699 |
| Interaction | Prl-3 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000078,regulation; IT:0000271,express; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 18471976_0, The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation.
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| Reference | 18471976_4, Consistent with a role in DNA damage-induced cell-cycle arrest, Prl-3 overexpression induces G(1) arrest downstream of p53 by triggering a PI3K-Akt-activated negative feedback loop.
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